Euglena 's colorectal cancer inhibitory effect was published in the academic journal "Food & Function"
-Demonstration of the effect of paramylon, a component peculiar to Euglena, on the occurrence of precancerous lesions, and verification of drug use-

University of Hyogo
Euglena Co., Ltd.

Hyogo Prefectural University Faculty of Environment and Human Studies Advanced Food Science Research Center (Location: Himeji City, Hyogo Prefecture, Director: Toshiaki Watanabe) and Euglena Co., Ltd. (Headquarters: Bunkyo-ku, Tokyo, President: Mitsuru Izumo) are microalgae. Studies have shown that paramylon, a unique ingredient of Euglena (Japanese name: Euglena), has a colon cancer-suppressing effect, and the results are related to "Food & Function" published on October 8, 2013 (Tuesday). (Patent application: September 30, 2011).

　The three leading causes of death in Japan in recent years are cancer, heart disease, and cerebrovascular disease, and colorectal cancer is thought to have the highest prevalence among cancers in the near future. The background to this is changes in lifestyle and eating habits in recent years, and it has been reported that people who consume a large amount of high-fat diets have an increased risk of developing the disease, especially with the westernization of diets. In the study published this time, colon cancer-induced mice administered with DMH (1,2-Dimethylhydrazine), which is a chemical carcinogen, were used to Euglena, paramylon, and amorphous paramylon, which is a non-crystal of paramylon. We examined the cancer-suppressing effect.
　As a result, administration of DMH suppressed the onset of precancerous lesions (ACF: Aberrant Crypt Foci) seen in the development of colorectal cancer Euglena, 59% by ingestion of paramylon, and 73% by ingestion of amorphous paramylon. It became clear that it was done. In other words, Euglena was found to have an ACF generation inhibitory effect, suggesting that paramylon and amorphous paramylon are particularly involved in ACF generation suppression.

　Based on the verification results, we plan to elucidate the mechanism and verify the possibility of using it as a drug related to the suppression of colorectal cancer including Euglena

Number of ACFs in the large intestine mucosa

<About Hyogo Prefectural University>
President: Masayoshi Kiyohara
Headquarters location: 8-2-1 Gakuen Nishimachi, Nishi-ku, Kobe City, Hyogo Prefecture
Founded: April 2004

<About Euglena Co., Ltd.>
President and CEO: Mitsuru Izumo
Capital: 919.38 million yen
Head Office: 7-3-1 Hongo, Bunkyo-ku, Tokyo 7th floor, University of Tokyo Entrepreneur Plaza
Business: We are developing and selling functional foods and cosmetics using microalgae Euglena (Japanese name: Euglena), and conducting research for carbon dioxide fixation and biofuel production. Listed on TSE Mothers in December 2012.

<Glossary>
Euglena: A type of algae (Japanese name: Euglena) that grows by photosynthesis while absorbing carbon dioxide as well as being a foodstuff with 59 kinds of abundant nutrients such as vitamins, essential amino acids, and DHA. Since it is a raw material for biofuels and biofuels, it is attracting attention as a material that helps solve food and environmental problems.
Paramylon is a component peculiar to Euglena, and is a polysaccharide in which glucose molecules are linearly polymerized by β-1,3-bonds. Euglena stores the energy acquired by itself as a stored polysaccharide in the cell.

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-Contact for inquiries from the press-
Euglena Co., Ltd. Public Relations and IR Division