Paramylon, a unique component of the microalgae Euglena
Confirmed research results suggesting suppression of chronic kidney disease

Euglena Co., Ltd.

　Euglena Co., Ltd. (Headquarters: Minato-ku, Tokyo, President: Mitsuru Izumo) is a microalga Euglena (Japanese name: Euglena, based on research with Dr. Yoshiyasu Nagayama, Mizoguchi Hospital, Faculty of Medicine, Teikyo University. Below, we have obtained research results suggesting that paramylon, a stored polysaccharide of "Euglena"), suppresses chronic nephropathy. The results of this research were published in "PLOS ONE" on August 7, 2020. (Https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237086)

■ Purpose of research
　 The kidneys filter blood and excrete waste products, including uremic toxins, as urine, but in patients with chronic kidney disease, kidney function is reduced to less than 60% of healthy people, and renal function is abnormal. Continue. As chronic renal disorder progresses, ^{the filtering function of glomeruli * 1} weakens, causing uremia to accumulate in the blood, which causes further progression of renal dysfunction and renal fibrosis ^{* 2}, resulting in myocardial infarction. It is said that it also leads to the onset of cardiovascular diseases such as stroke and stroke. In this study, we investigated the effect of continuous paramylon intake on the progression of chronic kidney disease in rats with chronic kidney disease.
* 1 Tissue that has the function of filtering waste products and salt in the blood in the kidney.
* 2 Symptoms of hardening of kidney tissue due to accumulation of collagen during chronic inflammation

■ Research content and results
It was suggested that paramylon intake suppresses chronic kidney disease
　 Rats with chronic kidney disease were usually fed a normal diet, diets containing 5% paramylon, and for comparison, healthy rats without chronic kidney disease were usually fed. The test was conducted with the food (control) given in. As a result, the increased excretion of urinary protein bodies ^{* 3} due to the onset of chronic kidney disease was significantly suppressed by ingestion of paramylon (Fig. 1). In addition, glomerular sclerosis (Fig. 2A) and renal tubular ^{* 4} disorders (Fig. 2B) observed by developing chronic kidney disease were significantly suppressed by ingestion of paramylon.
* 3 Protein is excreted in urine when kidney damage occurs.
* 4 Tissue responsible for reabsorbing amino acids, glucose, minerals, etc. from urine after being filtered by the glomerulus

* 5 A photograph of a cross-sectional view of the glomerulus. The arrow part represents the cured part. The higher the score, the harder it is
* 6 The arrow part indicates the damaged renal tubule. The higher the score, the more impaired

　These results suggest from a clinical and histological point of view that paramylon intake suppresses chronic kidney disease.
　We will continue to Euglena and Paramylon in health foods and medical fields, and increasing added value as foodstuffs.

<About Euglena (Japanese name: Euglena)>
Ishigakijima Euglena is a type of algae similar to wakame seaweed, kelp, and chlorella. It has the characteristics of both animals and plants, and has a well-balanced balance of 59 types of nutrients such as vitamins, minerals, amino acids, and unsaturated fatty acids. Includes. Paramylon, which is a component unique to Euglena and is a type of β-glucan, has been studied for its functionality in recent years and is expected to be used in the healthcare field such as foods and cosmetics. We capture the facts of the interrelationships of "malnutrition," "mental and physical fatigue," and "immunity weakness," and focus on the complex factors that hinder the foundation of health. It is important to achieve sustainable health, not temporary, by maintaining the body's original cycle of "creating, working, and protecting" and improving it to a better state, regardless of factors that hinder the foundation of health. I think.

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