For refreshment, agility, and liveliness that support healthy life expectancy!
Human clinical trials confirmed that continuous intake of Euglena effectively contributes to brain condition
-Confirmed an increase in brain-derived neurotrophic factor (BDNF), improvement in cognitive function speed / exercise speed, and improvement in mental health score-

Euglena Co., Ltd.

　Euglena Co., Ltd. (Headquarters: Minato-ku, Tokyo, President: Mitsuru Izumo) is a brain nerve cell by continuously ingesting Euglena (Japanese name: Euglena Brain-derived neurotrophic factor (BDNF), which is an essential protein for increasing euglena, is increased, the speed at which the body moves (cognitive function speed * ¹, exercise speed * ²) is improved by commands from the brain, and the mental health score is improved. We confirmed the research results showing.
　The results of this research were presented at the 73rd Annual Meeting of the Japanese Society of Nutrition and Food Science, which was held from May 17th to 19th.
* 1 Cognitive function speed: Indicates the speed at which the brain and body understand and react to information and things, and correlates with the amount of physical activity as well as the amount of exercise.
* 2 Exercise speed: When the exercise speed decreases, the motor function of the body may decrease.

~ Release points ~
By continuous intake of Euglena
(1) Confirmed an increase in BDNF, a protein essential for increasing brain cells.
→ BDNF is known to decrease in dose in patients with Alzheimer's disease and depression.

(2) Confirmed improvementin score by measuring cognitive function speed and exercise speed in the brain.
→ It was shown that there is a possibility of avoiding unexpected dangers (eg, falling due to obstacles) and making it easier to move the body more quickly.

③ Confirmed improvement in the score regarding psychological health in daily life.
→ It was shown that it may be possible to support a lively and calm feeling.

■ Purpose of research, implementation method
It is said that the difference between healthy life expectancy and healthy life expectancy, that is, the period of living with health problems, is about 9 years for men and about 12 years for women in Japan (Fig. 1). In addition, the brain is the most important tissue in information transmission through nerves such as movement and perception, and also plays an important role in mental activities such as emotions, emotions, and reason.

Material: Ministry of Health, Labor and Welfare 2018 "11th Health Japan 21 (Second) Promotion Expert Committee" [Material 1-1] ① 1. Created based on the materials created in Extending Healthy Life Expectancy and Reducing Health Disparities (p5)
Figure 1: Difference between healthy life expectancy and average life expectancy

　In this clinical trial, we will Euglena how continuous intake of euglena powder affects the condition of the brain and the health problems associated with it, after menopause, aged between 50 and 70 years old, without any health problems. Euglena powder or Euglena 3 times a day after breakfast, lunch and dinner for 24 weeks, before and until the 24th week after the start of intake. During this period, we conducted (1) blood tests, (2) tests on brain and body movements (cognitive function), and (3) questions about psychological health. The study was conducted in a double-blind, placebo-controlled trial * 3.
* 3 Double-blind, placebo-controlled trial: A study conducted by both the evaluator (doctor / staff) and the subject who are conducting the study, without knowing which test meal each group is eating. It is said that more reliable results can be obtained.

■ Results
　Euglena powder showed the following results:
　(1) Increase in BDNF in blood, which is a protein essential for increasing brain cells
　② Improvement of body movement speed (cognitive function speed / exercise speed) by command from the brain
　③ Improvement of mental health score as health-related QOL (quality of life)
　The details of the test contents are as follows.

① Increase in blood BDNF level
　When the amount of brain-derived neurotrophic factor (BDNF) in the blood was measured, the amount of change in BDNF in the blood at 24 weeks was significantly higher than that in the group that took the placebo powder.

②Improvement of cognitive function speed and exercise speed in brain function
　As a result of measuring the cognitive function speed and motor speed in brain function in a ^{7-item test * 4} such as language, vision, and information processing ability, the cognitive function speed was 12 weeks and the amount of change in the score of the Euglena It increased significantly compared to the intake group. Regarding exercise speed, it was confirmed that the amount of change in the scores at the 12th and 24th weeks was significantly increased in Euglena
　* 4 Measured by a cognitive function test using a personal computer called Cognitrax.

③ Improvement of mental health score
We asked questions about the health condition and daily activities of the past month, and calculated the psychological health score in daily life * 5. As a result, the changes in the mental health scores at the 6th, 12th, and 24th weeks in Euglena
　* 5 Measured with SF-36. SF-36 is a health-related QOL (quality of life) measurement method consisting of 36 questions. Regarding mental health, a high score means "feeling calm, fun, and calm", and a low score means "always feeling nervous and depressed".

<About microalgae Euglena >
Microalgae Euglena (Japanese name: Euglena) is a type of alga that has the characteristics of both plants and animals and contains abundant types of nutrients such as vitamins and minerals in a well-balanced manner. In 2005, Euglena Co., Ltd. succeeded in mass edible outdoor culture for the first time in the world.

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-Contact for inquiries from the press-
Euglena Co., Ltd. Corporate Communication Division