Confirmed the effect of suppressing the accumulation of fat droplets by the extract of microalgae Euglena

Euglena Co., Ltd.

　Euglena Co., Ltd. (Headquarters: Minato-ku, Tokyo, President: Mitsuru Izumo) is a hot water extract of microalgae Euglena (Japanese name: Euglena, hereafter Euglena). , Euglena hot water extract) was added to human adipose tissue-derived stem cells, and the effect of suppressing the accumulation of lipid droplets * 1 was confirmed.​ ​* 1 Droplets of spherically accumulated lipids observed in cells

　Obesity is a typical symptom of lifestyle-related diseases and refers to an abnormal health condition in which excess body fat is accumulated. In this test, human adipose tissue-derived stem cells to which a reagent that induces differentiation into adipocytes was added were set to a group in which Euglena hot water extract was added according to concentration and a group in which it was not added (control) to adipocytes. The state of adipocyte accumulation due to differentiation was compared by Oil Red O staining. At the same time, the expression level of genes related to adipocyte differentiation was measured.
　As a result, in the group to which Euglena hot water extract was added, the accumulation of lipid droplets was significantly suppressed as compared with the control, and the expression of genes related to adipocyte differentiation was suppressed.
　The above research results were published in the online version of the academic journal "PLoS ONE" on February 15, 2018. Going forward, we will continue to carry out research and development with the aim of utilizing the Euglena
　The details are as follows.

About test results on adipocyte differentiation suppression of microalgae Euglena

■ Research content
　For human adipose tissue-derived stem cells to which a reagent that induces differentiation into adipocytes has been added, a group in which Euglena hot water extract is added according to concentration and a group in which it is not added (control) are set, and lipid droplets due to differentiation into adipocytes are set. The state of accumulation was compared by Oil Red O staining. Furthermore, the expression level of genes related to adipocyte differentiation was measured by real-time PCR method * 2.​ ​* 2 Technology that enables real-time monitoring and analysis of gene expression levels

■ Results
　Euglena hot water extract was added to human adipose tissue-derived stem cells that were artificially induced to differentiate into adipocytes, the Euglena hot water extract, the more significant the accumulation of lipid droplets was compared with the control. Was suppressed. In the group to which Euglena hot water extract was added, the expression of genes related to adipocyte differentiation was suppressed.

* PPARγ and C / EBPα are both genes related to adipocyte differentiation.

■ Consideration
　Euglena hydrothermal extract suppresses the expression of genes related to adipocyte differentiation, and as a result, it has been shown that it may be involved in obesity prevention by suppressing the accumulation of lipid droplets.

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